The O-GlcNAc transferase (OGT) inhibitors disclosed thus far are burdened with certain shortcomings. We have incorporated OSMI-4, a nanomolar OGT inhibitor, into PROTACs. The prepared chimeras failed to induce effective OGT degradation or influence O-GlcNAcylation levels in MM.1S cells.
A. Bricelj, D. Novak, L. Smrdel, C. Steinebach, I. Sosič, M. Anderluh and M. Gobec, RSC Adv., 2025, 15, 25717 DOI: 10.1039/D5RA02801A
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