Issue 24, 2025, Issue in Progress

Ultrasensitive dopamine detection using CsPbBr3-PQD-COF nanocomposites: a synergistic fluorescence and EIS approach

Abstract

This study presents a novel dual-mode sensing platform for ultrasensitive dopamine (DA) detection using CsPbBr3 perovskite quantum dot (PQD)-integrated covalent organic framework (COF) (CsPbBr3-PQD-COF) nanocomposites. Leveraging the synergistic effects of fluorescence quenching and electrochemical impedance spectroscopy (EIS), the CsPbBr3-PQD-COF nanocomposites achieve exceptional sensitivity with limits of detection of 0.3 fM (fluorescence) and 2.5 fM (EIS), spanning a wide linear range from 1 fM to 500 μM. The platform exploits the optoelectronic properties of CsPbBr3 PQDs and the π-conjugated COF scaffold, enabling selective DA recognition via electron transfer and π–π stacking interactions. Incorporation of rhodamine B provides a visual green-to-pink shift at DA concentrations above 100 pM, enhancing practical utility. Specificity is demonstrated against common interferents (e.g., ascorbic acid, uric acid), with minimal cross-reactivity (<6%). In real-sample validation, the sensor exhibits excellent recovery (97.5–103.8% in human serum; 97.9–99.7% in PC12 supernatant) and stability over 30 days. This multimodal approach, combining femtosecond sensitivity, broad dynamic range, and visual indication, positions the CsPbBr3-PQD-COF nanocomposite as a promising tool for neurotransmitter monitoring in biomedical and clinical applications.

Graphical abstract: Ultrasensitive dopamine detection using CsPbBr3-PQD-COF nanocomposites: a synergistic fluorescence and EIS approach

Supplementary files

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Article information

Article type
Paper
Submitted
06 Apr 2025
Accepted
13 May 2025
First published
04 Jun 2025
This article is Open Access
Creative Commons BY license

RSC Adv., 2025,15, 18875-18892

Ultrasensitive dopamine detection using CsPbBr3-PQD-COF nanocomposites: a synergistic fluorescence and EIS approach

M. Kedhim, V. Jain, S. Ballal, A. Kumar, A. Singh, V. Kavitha, R. Panigrahi and H. Noorizadeh, RSC Adv., 2025, 15, 18875 DOI: 10.1039/D5RA02376A

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