Issue 18, 2025, Issue in Progress
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RSC Advances

Expansinine, a novel indole alkaloid–ergosteroid conjugate from the endophytic fungus Penicillium expansum of Aconitum carmichaelii†

Chenzhe Li, ORCID logo a   Ziruo He,a   Zhaofei Wen,a   Guangqian Sun,a   Xianying Tang,a   Tianpeng Yin ORCID logo *b  and  Le Cai*a  

* Corresponding authors

a Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Institute of International Rivers and Eco-security, School of Chemical Science and Technology, Yunnan University, Kunming 650091, P. R. China
E-mail: caile@ynu.edu.cn

b School of Bioengineering, Zunyi Medical University, Zhuhai, China
E-mail: ytp@zmu.edu.cn

Abstract

The endophytic fungus Penicillium expansum WTJP1 was isolated from Aconitum carmichaelii Debeaux, a famous traditional Chinese medicine known as aconite. Chemical investigation of this aconite-derived fungus led to the isolation of one previously undescribed compound, expansinine (1), which represents the first example of an indole alkaloid–ergosteroid conjugate found in nature. The assignments of the structure of 1 were determined by extensive spectroscopic and spectrometric ECD and DP4+ probability analyses. In addition, compound 1 was evaluated for its cytotoxic activities against five human cancer cell lines.

Graphical abstract: Expansinine, a novel indole alkaloid–ergosteroid conjugate from the endophytic fungus Penicillium expansum of Aconitum carmichaelii

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Article information

DOI
https://doi.org/10.1039/D5RA02287H
Article type
Paper
Submitted
02 Apr 2025
Accepted
23 Apr 2025
First published
02 May 2025
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2025,15, 14283-14288

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Expansinine, a novel indole alkaloid–ergosteroid conjugate from the endophytic fungus Penicillium expansum of Aconitum carmichaelii

C. Li, Z. He, Z. Wen, G. Sun, X. Tang, T. Yin and L. Cai, RSC Adv., 2025, 15, 14283 DOI: 10.1039/D5RA02287H

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