Issue 21, 2025, Issue in Progress

Advances in transition-metal catalyzed C–H bond activation of amidines to synthesize aza-heterocycles

Abstract

Amidine compounds, as important nitrogen analogues of isoelectronic carboxylic acids, are found throughout biologically active molecules and serve as the most attractive precursors for the synthesis of N-containing compounds. In this review, the advancements in the synthesis of aza-heterocycles via transition-metal catalyzed C–H bond activation of amidines have been summarized through diverse annulation reactions. Amidines act as two-electron donors via the more basic and less sterically crowded imino lone pair and coordinate with transition-metals, in which N–H imine could act as both directing group and intramolecular nucleophile, electrophile or proton acceptor. The mechanisms of different annulation pathways will be highlighted in this review along with a discussion of more recent developments in the field.

Graphical abstract: Advances in transition-metal catalyzed C–H bond activation of amidines to synthesize aza-heterocycles

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Article information

Article type
Review Article
Submitted
31 Mar 2025
Accepted
13 May 2025
First published
20 May 2025
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2025,15, 16921-16938

Advances in transition-metal catalyzed C–H bond activation of amidines to synthesize aza-heterocycles

J. Ren, Y. Xiong, Q. Li, B. Wang, G. Wang, B. Wang, H. Liu and X. Yang, RSC Adv., 2025, 15, 16921 DOI: 10.1039/D5RA02241J

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