Enzyme-catalyzed C(sp3)–H aminations for the highly enantioselective construction of chiral 2-oxazolidinones

Abstract

As a rapidly growing field, C(sp³)–H functionalization is being used to access a wide range of important molecular targets. The enzymatic activity of C(sp³)–H is a powerful synthetic tool to develop valuable building blocks. In this study, engineered myoglobin variants were found to be capable of C(sp³)–H activation under mild conditions via mediated nitrene transfer. Using this approach, 2-oxazolidinones and γ-lactams with high enantioselectivity were obtained through intramolecular cyclization using readily available and stable N-acetoxyamides as substrates.