The stereo-divergent functionalization of alkynes: a comprehensive review

Abstract

Alkynes are central in crafting pharmaceuticals, agrochemicals, and materials owing to their reactivity and linear geometry. This review unveils cutting-edge advancements in the stereo-divergent functionalization of alkynes, transforming them into invaluable tools for synthesizing stereochemically defined alkenes and alkanes. The review highlights ground-breaking methodologies that achieve exceptional E- and Z-selectivity using innovative catalysts like cobalt, nickel, and palladium through hydrogenation, hydroboration, and hydrosilylation. Recent breakthroughs such as dual-catalytic systems and energy transfer catalysis enable unprecedented stereocontrol. Sustainable strategies including water as a hydrogen source and recyclable catalysts align with green chemistry principles, paving the way for eco-friendly synthesis. This synthesis of cutting-edge techniques and their applications inspire new avenues in synthetic chemistry, offering transformative tools for creating complex molecular architectures with precision and sustainability.