Issue 14, 2025, Issue in Progress

Catalyst-free synthesis of 1,2,3-triazole-N-oxide derivatives using tert-butyl nitrite: a novel strategy and synthetic applications

Abstract

A simple, metal-free method has been developed to synthesize novel 1,2,3-triazole-N-oxide derivatives. In this reaction, t-BuONO serves as a NO source, with environmentally friendly solvents such as EtOH and H2O employed as additives. Control experiments provided valuable insights into the reaction mechanism. Furthermore, 1,2,3-triazole-N-oxides demonstrated versatility in synthetic transformations.

Graphical abstract: Catalyst-free synthesis of 1,2,3-triazole-N-oxide derivatives using tert-butyl nitrite: a novel strategy and synthetic applications

Supplementary files

Article information

Article type
Paper
Submitted
24 Feb 2025
Accepted
26 Mar 2025
First published
04 Apr 2025
This article is Open Access
Creative Commons BY license

RSC Adv., 2025,15, 10574-10581

Catalyst-free synthesis of 1,2,3-triazole-N-oxide derivatives using tert-butyl nitrite: a novel strategy and synthetic applications

K. Perumal, M. Shanthi, V. Hemamalini, B. Shankar and S. Ramesh, RSC Adv., 2025, 15, 10574 DOI: 10.1039/D5RA01327E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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