A brief review on the palladium-catalyzed C–H activation reactions of 2-phenylpyridines

Abstract

Transition metal-mediated C–H activation is a significant synthetic methodology, with palladium-catalysed C–H activation emerging as a powerful tool in organic synthesis. This review summarises the advances made by palladium-catalyzed C–H functionalisation reactions on the ortho position of 2-phenyl pyridine over the last two decades. The ortho position of 2-phenyl pyridine has been identified as a prime target for C–H activation due to its unique electronic and steric properties. This mild and selective transformation has enormous applications in the chemical field, such as drug discovery, natural products, agrochemical, and pharmaceutical industries. These highly regioselective, chemo-selective, eco-friendly reactions exhibit a wide substrate scope. This review accounts for the development of various palladium-catalyzed C–H functionalisation reactions of 2-phenyl pyridine.