Investigation of decellularized live hyaline cartilage graft material for efficient treatment of knee cartilage defects

Abstract

We first studied the structural morphology and thermal stability properties of decellularized live hyaline cartilage grafts (DLHCG) material, and further explored its short-term clinical efficacy in treating knee cartilage effects. The DLHCG material show good porous gel properties, excellent human compatibility, and chemical stability. We surgically implanted the DLHCG material into patients with articular cartilage defects and evaluated the effectiveness of its treatment using magnetic resonance imaging (MRI) as a characterization tool. This work proves that the DLHCG material can repair cartilage defects in the knee joint without adverse reactions in patients, and has good clinical application value.