Issue 20, 2025

Direct and selective nanosensor for amyloid-β oligomers in serum for Alzheimer's disease diagnosis

Abstract

The rising prevalence of Alzheimer's disease (AD) highlights an urgent need for ultra-sensitive diagnostic tools that facilitate early detection and intervention. Soluble Aβ oligomers (AβOs) have emerged as a key focus due to their specificity for AD pathology. This study introduces a magnetic nanoplatform-based ultrasensitive diagnostic assay for AβO detection, utilizing a novel custom-designed AβO-selective fluorophore, named O-SLM. This innovative approach achieves a sensitivity nearly tenfold greater than that of a comparative ELISA kit, with a detection limit as low as 25 fM. The assay requires minimal sample volumes and streamlines the protocol by omitting detection antibodies. It effectively distinguishes AD patients from healthy individuals through serum AβO quantification, demonstrating the versatility of our ultra-sensitive assay across various biomarkers.

Graphical abstract: Direct and selective nanosensor for amyloid-β oligomers in serum for Alzheimer's disease diagnosis

Supplementary files

Article information

Article type
Paper
Submitted
12 Feb 2025
Accepted
05 May 2025
First published
15 May 2025
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2025,15, 16175-16182

Direct and selective nanosensor for amyloid-β oligomers in serum for Alzheimer's disease diagnosis

Q. Song, H. Zhang, Y. Lan, J. Kong, M. S. Wong and H. Li, RSC Adv., 2025, 15, 16175 DOI: 10.1039/D5RA01020A

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