Corey–Fuchs reaction enabled synthesis of natural products: a review

Abstract

Natural products can be derived from a vast array of animals, plants and microorganisms and are generally characterized by a wide spectrum of bioactive properties such as anti-viral, anti-cancer, anti-inflammatory and anti-bacterial properties. Synthesis of natural products is of paramount importance in various fields including medicine, biotechnology and agriculture. The Corey–Fuchs reaction, also known as the Ramirez Corey–Fuchs reaction, is a pivotal organic transformation and plays a significant role in the synthesis of intricate natural products and their analogues. This review article highlights the development of the Corey–Fuchs reaction in recent years towards the synthesis of complex natural products including polyketides, alkaloids, terpenoids and peptides.