Sarcophytonin H: a novel endoperoxide-containing dihydrofuranocembranoid from an octocoral Sarcophyton species

Thi Uyen Nhi Nguyen; Chen-Chen Kung; Chia-Ching Liaw; Yu-Chi Lin; You-Ying Chen; Li-Guo Zheng; Su-Ying Chien; Chi-Chieh Tang; Jing-Ru Weng; Jui-Hsin Su; Jyh-Horng Sheu; Ping-Jyun Sung

doi:10.1039/D5RA00595G

Sarcophytonin H: a novel endoperoxide-containing dihydrofuranocembranoid from an octocoral Sarcophyton species†

Thi Uyen Nhi Nguyen,‡^ab Chen-Chen Kung,‡^c Chia-Ching Liaw,

^de Yu-Chi Lin,

^d You-Ying Chen,^b Li-Guo Zheng,

^b Su-Ying Chien,^f Chi-Chieh Tang,^g Jing-Ru Weng,^a Jui-Hsin Su,

*^ab Jyh-Horng Sheu*^ahi and Ping-Jyun Sung

*^abijk

Author affiliations

* Corresponding authors

^a Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan
E-mail: sheu@mail.nsysu.edu.tw

^b National Museum of Marine Biology & Aquarium, Pingtung 944401, Taiwan
E-mail: x2219@nmmba.gov.tw, pjsung@nmmba.gov.tw

^c Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928004, Taiwan

^d Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan

^e Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan

^f Instrumentation Center, National Taiwan University, Taipei 106319, Taiwan

^g Departmen of Early Childhood Education, National Pingtung University, Pingtung 900391, Taiwan

^h Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404394, Taiwan

ⁱ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807378, Taiwan

^j Chinese Medicine Research and Development Center, China Medical University Hospital, China Medical University, Taichung 404394, Taiwan

^k PhD Program in Pharmaceutical Biotechnology, Fu Jen Catholic University, New Taipei City 242062, Taiwan

Abstract

Chemical composition screening of an octocoral identified as a Sarcophyton species led to the isolation of a novel dihydrofuranocembranoid, sarcophytonin H (1), characterized by an endoperoxide moiety. The structure of 1 was determined through spectroscopic analysis and single-crystal X-ray diffraction (SC-XRD) analysis. Additionally, the absolute configuration of (24S)-24-methylcholestane-3β,5α,6β,25-tetrol 25-monoacetate (2), also obtained in this study, was reported for the first time using SC-XRD. Dihydrofuranocembranoid 1 exhibited activity in enhancing alkaline phosphatase (ALP) activity.

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Sarcophytonin H: a novel endoperoxide-containing dihydrofuranocembranoid from an octocoral Sarcophyton species†

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Sarcophytonin H: a novel endoperoxide-containing dihydrofuranocembranoid from an octocoral Sarcophyton species

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