Issue 13, 2025, Issue in Progress
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RSC Advances

Molecular recognition and potentiometric determination of neostigmine and pyridostigmine by a methylene-bridged naphthotube†

Jian-Fang Wu,‡ab   Wen-Jie Chen,‡b   Li-Li Wang, ORCID logo b   Liu-Pan Yang, ORCID logo *b   Yan-Fang Wang ORCID logo *cd  and  Dehua Liao*a  

* Corresponding authors

a Department of Pharmacy, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410000, China
E-mail: liaodehua1125@126.com

b School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China
E-mail: yanglp@usc.edu.cn

c Department of Chemistry, Zhejiang University, Hangzhou 310058, P. R. China
E-mail: 11930562@mail.sustech.edu.cn

d ZJU-Hangzhou Global Scientific and Technological Innovation Center, ZhejiangUniversity, Hangzhou 311215, P. R. China

Abstract

A macrocyclic arene featuring rigid bis-naphthalene possesses a remarkable ability to strongly bind neostigmine (Ka = 2.7 × 104 M−1) and pyridostigmine (Ka = 2.2 × 105 M−1) within its deep cavity. This facilitates the host as a potential ionophore for the potentiometric determination of neostigmine and pyridostigmine with low detection limits of 1.0 μM, highlighting its promising applications in pharmaceutical analysis.

Graphical abstract: Molecular recognition and potentiometric determination of neostigmine and pyridostigmine by a methylene-bridged naphthotube

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Article information

DOI
https://doi.org/10.1039/D4RA09021G
Article type
Paper
Submitted
26 Dec 2024
Accepted
24 Mar 2025
First published
31 Mar 2025
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2025,15, 9657-9661

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Molecular recognition and potentiometric determination of neostigmine and pyridostigmine by a methylene-bridged naphthotube

J. Wu, W. Chen, L. Wang, L. Yang, Y. Wang and D. Liao, RSC Adv., 2025, 15, 9657 DOI: 10.1039/D4RA09021G

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