Recent advances in the application of β-ketonitriles as multifunctional intermediates in organic chemistry

Abstract

This review discusses the diverse applications of β-ketonitriles in organic synthesis, highlighting protocols that generate various compounds, including cyclic hydrocarbons, aromatic compounds, heterocycles, spirocycles, and fused heterocycles. These compounds serve as valuable building blocks for biologically active scaffolds like chromenes, quinolines, and natural products. It provides an overview of 69 research articles published from 2014 to 2023, focusing on reactions involving benzoyl acetonitrile derivatives and other β-ketonitriles. The methodologies include cascade, domino, and sequential reactions facilitated by different catalysts, showcasing the versatility of β-ketonitriles in organic chemistry.