Synthesis and application of a bimetallic-MOFs with sulfonic acid tags in preparation of biologically active nicotinonitriles via cooperative vinylogous anomeric-based oxidation

Abstract

Bimetallic-organic frameworks (bimetallic-MOFs) have broad capabilities owing to the synergistic properties of two metals in a single structure. In this regard, we prepared a bimetallic-MOF containing iron (Fe) and nickel (Ni) metals. The prepared bimetallic-MOF was functionalized with sulfonic acid groups via a post-modification method. Thus, a new acidic catalyst with special abilities was prepared. The physicochemical properties of the bimetallic-MOF containing sulfonic acid groups were investigated through FT-IR, SEM, BET/BJH, XRD, EDS, elemental mapping and TGA/DTG analyses. According to the acidic active sites in the structure of the presented catalyst, we investigated the performance of this catalyst in the synthesis of nicotinonitrile derivatives. The structure of the products was also confirmed using melting point, FT-IR, HR-mass, ¹H-NMR, and ¹³C-NMR analyses. Moreover, the antibacterial properties of the synthesized product and MIL-88B(Fe₂/Ni)/imidazole/SO₃H were investigated, and results showed satisfactory antibacterial properties of these compounds against Gram-positive and Gram-negative bacteria.