Access to spiro-isoxazoline via a palladium-catalyzed carboetheri-fication of cycloalkenyl-tethered oximes

Abstract

This study presents an efficient method for synthesizing spiro-isoxazolines through a tandem palladium-catalyzed carboetherification approach. Utilizing cycloalkenyl-tethered oximes and aryl/alkenyl bromides, this protocol enables the construction of a wide range of novel spiro-isoxazoline compounds bearing diverse functional groups. Furthermore, we also investigated the asymmetric version of this tandem reaction, where the use of a chiral tert-butanesulfinamide monophosphine ligand achieved good chemical yield and excellent enantioselectivity.