Palladium/photoredox catalysis for a decarboxylative radical C(sp3)–C(sp3) cross-coupling reaction of γ-methylidene-δ-valerolactones with alkyl carboxylic acids

Abstract

Developing applicable methods to forge linkages between sp³- and sp³-hybridized carbons is of great significance in drug discovery. Here, a radical decarboxylative C(sp³)–C(sp³) cross-coupling of γ-methylidene-δ-valerolactones (GMDVs) and alkyl carboxylic acids was developed by combining photocatalysis and palladium catalysis, providing the target products in good to excellent yields (up to 97% yield). The reaction exhibited a broad substrate scope and wide functional group compatibility.