Nucleophilic addition of sulfoxonium ylides to hypervalent iodine diazo compounds as N-terminal electrophiles: direct access to novel functionalized hydrazones

Abstract

A catalyst and additive-free nucleophilic addition of sulfoxonium ylides to hypervalent iodine diazo reagents as N-terminal electrophiles has been developed. The reaction not only leads to a facile access to highly functionalized hydrazones but also significantly advances the understanding of hitherto unexplored terminal N-electrophilicity in HIDCs. The operational simplicity, wide substrate scope, high product yields and mild conditions are notable features of the methodology.