Lumiflavine-catalyzed, visible-light-driven allylation of cyclobutanone oximes: a sustainable approach to distally unsaturated nitriles

Abstract

We present a naturally derived organophotoredox catalyst system for the ring-opening allylation of cyclobutanone O-acetyl oxime esters. This metal-free process operates under mild and environmentally benign conditions, demonstrating broad substrate compatibility. A range of distally unsaturated nitriles was synthesized in good to excellent yields with high stereoselectivity.