Copper-catalyzed stereo-controllable silylation of allylic gem-dichlorides

Abstract

Herein, we present a ligand-regulated, stereo-controllable silylation reaction of allylic gem-dichlorides. In the absence of ligand, the reaction yields (Z)-vinyl chlorides with high stereoselectivity. Conversely, using a chiral Pybox ligand leads to the formation of (E)-vinyl chlorides with high enantioselectivity. This method demonstrates broad substrate compatibility, effectively producing the desired (Z)- and (E)-vinyl chloride products from a variety of aliphatic and aromatic allylic gem-dichlorides.