Radical-polar crossover cyclization: visible-light-induced synthesis of γ-alkylated 1,1-disubstituted cyclopropanes via 1,6-hydrogen atom transfer

Abstract

A visible-light-induced radical-polar crossover cyclization (RPCC) reaction between homoallylic substrates and sulfamate esters for the synthesis of γ-alkylated 1,1-disubstituted cyclopropanes via 1,6-HAT processes has been reported. This protocol displays mild and metal-free conditions, excellent functional group tolerance and a broad range of substrates. Furthermore, the potential synthetic potential of this transformation is demonstrated by scale-up reactions and synthetic applications.