Axially chiral biaryls via rhodium-catalyzed atroposelective C–H sulfenylation and selenylation†
Abstract
Transition metal-catalyzed atroposelective C–H activation has become an efficient approach for the rapid construction of functionalized axially chiral biaryls, but remains challenging in the synthesis of chalcogenated axially chiral biaryls due to the strong binding affinity between the chalcogen and metal center. Herein, we report an efficient rhodium-catalyzed atroposelective C–H chalcogenation of biaryls with readily accessible disulfides and diselenides. The reaction occurs in the presence of a silver salt as a chalcophile to regenerate the active chiral rhodium catalyst. This protocol features a broad scope and mild conditions, affording a series of axially chiral biaryl sulfides and selenides in excellent yields and enantioselectivities.