Enantioselective addition of 3-hydroxyquinolin-2(1H)-one to isatin and pyrazole-4,5-dione derived ketimines

Abstract

The enantioselective reactivity of 3-hydroxyquinolin-2(1H)-ones was developed through their addition to isatin and pyrazole-4,5-dione derived ketimines, affording novel architectures featuring multiple natural product scaffolds in high yields with excellent enantioselectivities. Gram-scale synthesis and synthetic transformations further disclosed the potential of the current process.