Palladium-catalyzed cascade decarboxylative cyclization of alkyne-tethered aryl iodides with o-bromobenzoic acids for the synthesis of fused isoquinolinones

Abstract

A palladium-catalyzed cascade decarboxylative cyclization of alkyne-tethered aryl iodides with o-bromobenzoic acids has been disclosed, which provides a straightforward entry to a range of fused isoquinolinone derivatives. The transformation involves cascade syn-carbopalladation, C–H activation, and a decarboxylation sequence, enabling the simultaneous formation of three C–C bonds. Furthermore, 8-bromo-1-naphthoic acid can act as a viable substrate to forge a seven-membered ring fused isoquinolinone.