From the journal:

Inorganic Chemistry Frontiers

Spherical mixed-valence pentadecavanadate binding to human H-chain ferritin

Rosanna Lucignano,†a   Gabriella Tito,†a   Giarita Ferraro,a   Delia Picone,a   Federico Pisanu, ORCID logo b   Eugenio Garribba ORCID logo *b  and  Antonello Merlino ORCID logo *a  

* Corresponding authors

a Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, via Cinthia 26, Naples, Italy
E-mail: antonello.merlino@unina.it

b Dipartimento di Medicina, Chirurgia e Farmacia, Università di Sassari, Viale San Pietro, I-07100 Sassari, Italy
E-mail: garribba@uniss.it

Abstract

The interaction of [VIVO(acac)2], acac = acetylacetonato, with H-chain ferritin has been studied. After dissociation and partial oxidation, [VIVO(acac)2] forms a mixed-valence [V15O36(Cl)]6− ion, which non-covalently binds with the protein nanocage. This polyoxidovanadate is formed at alkaline pH, showing that proteins can favor the formation and stabilization of species hardly isolable in solution.

Graphical abstract: Spherical mixed-valence pentadecavanadate binding to human H-chain ferritin

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Article information

DOI
https://doi.org/10.1039/D5QI01694K
Article type
Research Article
Submitted
11 Aug 2025
Accepted
20 Aug 2025
First published
22 Aug 2025
This article is Open Access
Creative Commons BY-NC license

Inorg. Chem. Front., 2025, Advance Article

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Spherical mixed-valence pentadecavanadate binding to human H-chain ferritin

R. Lucignano, G. Tito, G. Ferraro, D. Picone, F. Pisanu, E. Garribba and A. Merlino, Inorg. Chem. Front., 2025, Advance Article , DOI: 10.1039/D5QI01694K

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