Eutectic formulations in pharmaceutical development: a comprehensive review of modulation strategies

Abstract

Poorly soluble drugs pose significant challenges in terms of their pharmacokinetics and biopharmaceutical properties, reducing their therapeutic potential. Crystal engineering has emerged as a promising strategy to address this issue. This comprehensive review delves into the transformative potential of crystal engineering in designing eutectic multicomponent systems. Through the strategic exploitation of supramolecular synthons and non-covalent interactions, eutectic formulations demonstrate significantly improved solubilization, enhanced stability profiles, and augmented bioavailability. We explore the details of functional group interactions, molecular structural design, and crystal lattice dynamics to elucidate the underlying mechanisms governing eutectic formations. Our review provides a profound understanding of the interplay between crystal engineering and pharmacokinetics, paving the way for the rational design of eutectic formulations with optimized drug delivery and therapeutic outcomes.