Polysaccharide-capped silver nanoparticles impregnated cream for the efficient management of wound healing

Abstract

Developing wound-dressing materials that meet all the required qualities for curing burns and injuries caused by various diseases is a challenging task. However, the biocompatibility, biodegradability, and non-toxicity of natural polysaccharides make them an excellent base material for creating flexible and widely accepted formulations. To test this, we created a cream formulation that utilised galactomannan's non-toxic and immuno-stimulatory properties and added silver nanoparticles to create SNP@PSP. Preclinical studies were conducted in vitro and in vivo experiments in rat models to test the wound-healing capabilities of the formulation. The cream's ability to heal wounds was demonstrated through immunohistochemistry, collagen staining, and histopathology. Our work provides a formulation that utilises silver nanoparticles to create polysaccharide cream with improved biocompatibility and antibacterial properties. The rat wound-healing experiments showed that the cream was effective for clinical use, with the addition of nanosilver significantly boosting its antibacterial properties.