Polysaccharide-capped silver nanoparticles impregnated cream for the efficient management of wound healing

Abstract

Developing wound dressing materials that meet all the required qualities for curing burns and injuries caused by various diseases is a challenging task. However, natural polysaccharides' biocompatibility, biodegradability, and non-toxicity make them an excellent base material for creating flexible and widely accepted formulations. To test this, we created a cream formulation that utilised galactomannan's nontoxic and immuno-stimulatory properties and added silver nanoparticles to create SNP@PSP. Preclinical studies were conducted in vitro and in vivo experiments in rat models to test the wound-healing capabilities of the formulation. The cream's ability to heal wounds was demonstrated through immunohistochemistry, collagen staining, and histopathology. Our work provides a formulation that utilises silver nanoparticles to create polysaccharide cream with improved biocompatibility and antibacterial properties. The rat wound healing experiments showed that the cream was effective for clinical use, with the addition of nanosilver significantly boosting its antibacterial properties.