Iron-Catalyzed Decarboxylative Cyanoalkylation of α-Fluoroacrylic Acids

Abstract

A novel and practical protocol has been developed for the synthesis of cyano-containing monofluoroalkenes via iron-catalyzed decarboxylative cyanoalkylation. This method employs αfluoroacrylic acids and cycloketone oxime esters as coupling partners, enabling the efficient construction of C (sp²)-C (sp³) bonds under simple reaction conditions. The protocol exhibits good tolerance toward a variety of functional groups and demonstrates high stereoselectivity, providing a reliable strategy for the synthesis of fluorine-containing organic intermediates and the modification of complex bioactive molecules.