A series of aryl triazole derivatives with varying electronic substituents but comparable hydrophobicity were synthesized for chloride transmembrane transport. Their activity decreased as the electron-withdrawing strength weakened (EC50 ranging from 3.2 to 15.2 μM), establishing a clear structure-activity relationship and providing a key basis for designing efficient artificial anion transporters.
J. Fan, W. Wu, X. Dou, J. Huo, X. Tang, S. Li and C. Bao, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D6OB00449K
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