Deoxygenation of carboxylic acids-based radical-polar crossover process for modular access to functionalized cyclopropanes

Abstract

Herein, a photoredox-catalyzed strategy has been successfully developed for the preparation of arylformylmethyl cyclopropanes via acylative coupling of (hetero)aryl carboxylic acids with homoallyl tosylates. This deoxygenation-based radical-polar crossover process was also feasible for the preparation of 3-(cyclopropylethyl)chroman-4-ones via reactions of alkene-tethered carboxylic acids with homoallyl tosylate.