Synthesis of Furoquinolines from 2-Alkenylanilines via Anodic Dearomatization and Cascade Cyclization

Abstract

Herein, we report an anodic dearomatization followed by one-pot nucleophilic cycloaddition/Bischler-Napieralski reaction of 2alkenylanilines for the construction of structurally diverse dihydrofuro[2,3-g]quinolinones. This metal-free protocol features high atom economy and good functional group tolerance, providing an efficient and practical strategy for accessing dihydrofuro[2,3g]quinolinone scaffolds. Notably, the dihydrofuro[2,3-g]quinoline products are readily amenable to oxidation to afford the corresponding furo[2,3-g]quinolines with potential applications in bioactive molecule synthesis.