Practical and robust access to enimides via DMAPO-catalyzed coupling of carboxylic acids with secondary enamides

Abstract

Herein, a new protocol for the preparation of α-aryl N-vinylimides has been successfully developed. With carboxylic acids as the acyl source, a range of N-vinylamide could react with carboxylic acids enabled by DMAPO/Boc2O system. The applications of enimide as the radical acceptor for photocatalytic cyclopropanation and N→C acyl migration reactions were also demonstrated. This acylation method features broad substrate scopes and good functional group tolerance.