A mild and regioselective nitration–cyclization of alkynyl aryl ketones has been developed to access 3-nitroflavones promoted by Zn(OTf)2. Tandem nitration and intramolecular cyclization is achieved using 68% HNO3 under room-temperature conditions, delivering substituted 3-nitroflavones in generally good to excellent yields.
Y. Yang, C. Shao, R. Hua, R. Tian, Z. Wang, H. Yin, H. Zhu and F. Chen, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D6OB00238B
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