Photoinduced FeCl₃-Catalyzed α-C(sp³)-H Azolation of Primary Aliphatic Alcohols via LMCT-Driven HAT

Abstract

Herein, a visible-light-driven FeCl₃-catalyzed α-C(sp³)-H azolation/coupling reaction of primary aliphatic alcohols has been reported. The reaction achieves activation of the α-C(sp 3 )-H bond in the ether formed by dehydration of primary alcohols under mild conditions via an LMCT-promoted HAT process. The protocol is broadly applicable to substituted indazoles and other nitrogen-containing scaffolds common in medicinal chemistry, and is compatible with a wide range of primary aliphatic alcohols substrates. HAT O Scheme 1 α-C(sp 3 )-H azolation of ether or alcohols