We report a redox-neutral photocatalytic strategy for the difunctionalization of α,β-unsaturated amides, enabling αnucleophilic fluorination and β-phosphonylation via an α-carbonyl cation intermediate. This transformation employs an organic photocatalyst, CBZ6, and proceeds at room temperature, furnishing a series of valuable α-fluoro-β-phosphonoyl amides within 1 hour.
F. Wang, J. Gong, W. Shao, L. Lin, Y. Chen, Y. Kang and J. Qu, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D6OB00181E
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