A highly efficient and practical iodine-catalyzed Z-to-E isomerization of enamides under mild conditions is developed. The method exhibits broad substrate scope. Its synthetic utility is demonstrated by gram-scale synthesis and late-stage modification of biorelevant compounds. A plausible mechanism involving iodination, C-C bond rotation, and protodeiodination is proposed.
To support increased transparency, we offer authors the option to publish the peer review history alongside their article.
Y. Yuan, W. Wang, Y. Wang, D. Feng, S. Peng, C. Ge and P. Huang, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D6OB00155F
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...
