Regio- and Stereoselective Ring-Opening of Aziridines: A Click Chemistry Approach to Chiral Amino Alcohols and Triazole-Modified Compounds

Abstract

The presented paper describes a regio-and stereoselective method for synthesizing of chiral amino alcohol derivatives from simple, readily available substrates such as chiral epoxides and chiral aziridines. By applying click chemistry principles, the method enables efficient synthesis of the target compounds in high yields while minimizing purification steps, making it both cost-effective and environmentally friendly. The regiochemistry and stereochemistry of the products were confirmed by X-ray crystallographic analysis. To demonstrate the method's versatility, a chiral atenolol derivative incorporating a 1,2,3-triazole ring and a luminescent subunit was also synthesized.