A metal-free, iodine-mediated amination enables a one-pot synthesis of indole-embedded dihydropyrazoles with broad substrate scope. The lead compound 5qq exhibited potent antimicrobial activity (MIC = 4 µg/mL) via DNA gyrase inhibition, showed efficient bacterial uptake, and displayed negligible cytotoxicity up to 100 µM, highlighting its promise as an antimicrobial lead.
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A. Krishna, K. T. Ashitha, M. P. Bhat, M. Rudrappa, A. C. Santhoshkumar, L. Basha, S. Varughese, N. Vankadari, S. Nayaka and B. S. Sasidhar, Org. Biomol. Chem., 2025, Accepted Manuscript , DOI: 10.1039/D6OB00043F
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