A three-component 1,3-dipolar cycloaddition of pyrazolone derived azomethine ylides with succinimides for the construction of novel spiro-pyrazolone-pyrrolizines containing succinimides

Abstract

A three-component 1, 3-dipolar cycloaddition of maleimides with azomethine ylides generated in situ from pyrazolones and prolines has been developed, and a series of novel pharmaceutically interesting spiro-pyrazolone-pyrrolizines containing succinimides were obtained in moderate to excellent yields with poor to excellent diastereoselectivities.