Direct synthesis of dehydroselenocysteine-containing peptides from cysteine derivatives

Abstract

Dehydroamino acids are valuable building blocks for the construction of artificially designed functional peptides. However, effective approaches for the preparation of dehydroselenocysteine derivatives remain largely unexplored. Herein, we disclose a concise and direct method for the synthesis of dehydroselenocysteine derivatives from cysteine derivatives using diphenyl diselenide.