Electrochemical C-H Trifluoromethylation of 4-Phenylthiazol-2amines

Abstract

Herein, we report a new methodology for the electrochemical oxidative C–H trifluoromethylation of 4-phenylthiazol-2-amines in an undivided cell using a glassy carbon electrode (GCE) and sodium trifluoromethanesulfinate (CF3SO2Na; Langlois’ reagent) as the CF₃ radical source. Using this tert-butyl hydroperoxide (TBHP)-mediated and transition metal-free effective approach, trifluo-romethylated 4-phenylthiazol-2-amines were synthesized in high yields (up to 97%).