Electrochemical Cross-Electrophile Coupling of Unactivated Tertiary Alkyl Bromides with Benzyl Chloride to Access Quaternary Stereocenters

Abstract

Constructing quaternary carbon centers represents a significant yet challenging work in synthetic and medicinal chemistry. Herein, we report an efficient electrochemical nickel-catalyzed reductive crosselectrophile coupling for the modular synthesis of diverse quaternary carbon centers from readily available tertiary alkyl bromides and benzyl chlorides. This electrochemical protocol eliminates the dependence on stoichiometric metallic reductants, making this method more sustainable and attractive.