Gold-Catalysed N-Allenamide Cyclisation as a Platform for the Construction of Indole-Fused Quinoxaline and Quinoline Scaffolds

Abstract

We report a gold-catalysed cyclisation of N-allenamides derived from 1- and 2-(2-aminoaryl)indoles, providing easy access to 5,6-dihydroindolo[1,2-a]quinoxalines and 6,11-dihydro-5H-indolo[3,2-c]quinolines. The reaction proceeds under mild conditions, tolerates diverse functional groups, and enables the synthesis of previously unexplored indole-fused heterocycles, whose versatility was demonstrated through selected post-functionalisation reactions.