GREEN AND SUSTAINABLE NANOCATALYZED SYNTHESES OF HYBRID HETEROCYCLIC SCAFFOLDS WITH PRIVILEGED SUBSTRUCTURES

Abstract

The review article presents recent advances relating to the use of nanostructured catalysts in the construction of drug-like small hybrid molecules with structural diversity and molecular complexity incorporating medicinally privileged heterocyclic substructures. The nanocatalyzed synthetic methods and reaction mechanisms involving facilitation of reaction with the interactionof reacting molecules with nanostructured catalysts have also been included. The nanocatalyzed reactions will play a significant role in the design and synthesis of potential pharmaceutical products of structural complexity and desired activity with fused privileged heterocyclic substructures in their structures. Moreover, the nanocatalyzed synthetic methods are environmentally sustainable and will provide an access for a diverse range of natural product mimetic scaffolds with the use of combinatorial chemistry in the presence of environmentally sustainable reaction conditions. The present review article will contribute substantially not only to the organic syntheses, catalyses and material science but also to the pharmaceutical and medicinal chemistry including drug discovery research in exploring the future opportunity in medicinal chemistry.