Copper-catalyzed synthesis of functionalized dithioalkenes from solid calcium carbide

Abstract

A complementary strategy employing nucleophilic addition reactions was demonstrated, using calcium carbide as the acetylene source, 2-bromophenylthiophenol as substrate, and copper as catalyst. This approach is distinguished by its reliance on stable, easy-to-handle acetylene surrogates, broad substrate applicability, tolerance to open-air aqueous conditions, and facile scalability to gram-level synthesis.