This study presents a photoredox-catalyzed two-component alkylative coupling between silyl enol ethers and an N-trifluoroethyl hydroxylamine reagent via a radical 1,2-H shift, establishing a novel synthetic route toward β-trifluoromethyl β-aminoketones. The protocol offers exceptional efficiency, mild reaction conditions, and operational simplicity.
Y. Feng, S. Liu, W. Meng and Y. Huang, Org. Biomol. Chem., 2025, 23, 10929 DOI: 10.1039/D5OB01591J
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