Issue 44, 2025
From the journal:

Organic & Biomolecular Chemistry

Chimeric fungal–firefly luciferins exhibit red shifted fungal bioluminescence

Jude I. Ayogu,a   Minyan Lyu,a   Aleksei D. Barykin,bc   Anastasia A. Fadeeva,b   Zinaida M. Kaskova ORCID logo bd  and  James C. Anderson ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK
E-mail: j.c.anderson@ucl.ac.uk

b Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia

c Moscow Center for Advanced Studies, Kulakova str. 20, Moscow 123592, Russian Federation

d Pirogov Russian National Research Medical University, Moscow 117997, Russia

Abstract

A rational design of new luciferins based upon the combination of luciferins from different lineages is exemplified by the synthesis of chimeric luciferins from a combination of fungal and firefly luciferin. Two new chimeric fungal–firefly luciferins exhibited the furthest red shifted bioluminescence of a fungal luciferin analogue.

Graphical abstract: Chimeric fungal–firefly luciferins exhibit red shifted fungal bioluminescence

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Article information

DOI
https://doi.org/10.1039/D5OB01589H
Article type
Paper
Submitted
06 Oct 2025
Accepted
21 Oct 2025
First published
22 Oct 2025
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2025,23, 10186-10193

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Chimeric fungal–firefly luciferins exhibit red shifted fungal bioluminescence

J. I. Ayogu, M. Lyu, A. D. Barykin, A. A. Fadeeva, Z. M. Kaskova and J. C. Anderson, Org. Biomol. Chem., 2025, 23, 10186 DOI: 10.1039/D5OB01589H

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