Transition-metal-free synthesis of oxadiazole-tethered 1,2,3-triazoles from α-trifluoromethyl ketones, hydrazides and azides

Abstract

A concise one-pot three-component protocol for the assembly of 1,3,4-oxadiazole-tethered 1,2,3-triazoles from readily available starting materials has been disclosed. The reaction sequence begins with a formal [4 + 1] cycloaddition between α-trifluoromethyl ketones and hydrazides to furnish 1,3,4-oxadiazoles in situ, followed by a base-mediated 1,3-dipolar cycloaddition with aryl azides to afford the oxadiazole-tethered 1,2,3-triazoles in a single operation.