Silver-catalyzed diastereoselective cascade radical cyclization of CF3-alkenyl quinolones with diarylphosphine oxides

Abstract

A silver catalyzed phosphorus radical promoted cascade cyclization of quinolone derived unactivated olefins is described to access dual-functionalized dihydrophenanthridinones bearing phosphoryl and CF₃-carbinol groups. The reaction achieves concurrent C–P and C–C bond formation in one step, providing excellent yields and high diastereoselectivity (>20 : 1). The CF₃ group exerts a strong steric effect, which helps achieve remarkable diastereoselectivity.