Palladium-catalyzed asymmetric propargylic sulfonylation of propargyl esters with sulfonyl hydrazides

Abstract

Palladium-catalyzed enantioselective propargylic sulfonylation between racemic propargyl esters and readily available sulfonyl hydrazides with an N-benzylamino-bridged bidentate phosphoramidite (N-Bn-Me-BIPAM) ligand was reported. The corresponding reactions provided a series of enantiomerically rich propargylic sulfones in good yields with high enantioselectivity under mild reaction conditions.