Palladium-Catalyzed Asymmetric Propargylic Sulfonylation of Propargyl Esters with Sulfonyl Hydrazides

Abstract

A palladium catalyzed enantioselective propargylic sulfonylation was reported between racemic propargyl esters and readily available sulfonyl hydrazides with a N-benzylamino-bridged bidentate phosphoramidite (N-Bn-Me-BIPAM) as the ligand. The corresponding reactions provided a series of enantiomerically rich propargylic sulfones in good yields with high enantioselectivity under mild reaction conditions.